Inside ProleevaMax: 13 Ingredients, One Purpose

Natural Ingredients
Everyday Relief
Balanced Living
Natural Wellness
Sustained Comfort
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Curcumin

Curcumin, which is the main active ingredient of Turmeric, has powerful anti-inflammatory properties that promote soothing comfort in muscles and joints by blocking the COX-2 enzymes responsible for inflammation and pain. In addition, curcumin also boosts the activity of your body’s antioxidant enzymes. In that way,curcumin delivers a one-two punch against free radicals, blocking them directly and then stimulating antioxidant defenses.
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L-Arginine HCI

L-Arginine is an amino acid that has the ability to improve blood flow and clear out inflammation in the body. The antioxidant supplementation of L-Arginine restores the balance between reactive oxygen species and antioxidants, thereby protecting tissues from the harmful effects of oxidative stress.
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Matcha Green Tea Powder

It’s no secret that matcha green tea leaf powder has amazing antioxidative properties. Studies have shown that when matcha green tea is used in addition to a balanced diet, it can improve the overall antioxidative status and protect against oxidative damage within the body.
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Crafted by Nature, Perfected by Science

Our formula combines 13 natural ingredients, working in harmony to provide you with targeted, effective relief.
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Choline L-Bitartrate

Choline Bitartrate is critical for several functions across one’s life cycle, including a wide range of roles in the human metabolism, from neurotransmitter synthesis to cell structure and methylation. Choline Bitartrate is a dietary component and precursor of acetylcholine, a crucial neurotransmitter for memory-related brain functions. A combination approach of choline bitartrate has shown enhanced athletic performance, reduced cholesterol levels, protection from liver disease, control mood swings, improve memory, and even treat Alzheimer’s disease.
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Resveratrol

Japanese Knotweed (Polygonum cuspidatum Extract (root) 98% resveratrol) is a rich source of antioxidant agents that also provide anti-inflammatory potential. It helps prevent oxidative stress and improves cellular integrity. In the case of inflammation, studies reported that grape seed extract suppresses the release and expression of pro-inflammatory cytokines (IL-6, IL-8, IL-1β and tumor necrosis factor-alpha, etc.) responsible for inflammation progression or development [65]. Moreover, it modulates gut microbiota, improves gut immune response, and supports optimal gut microbiota. These gut health benefits may help the management of inflammatory conditions in the gastrointestinal tract. Additionally, grape seed extract supplementation increases the expression of anti-inflammatory cytokines such as interleukin-10 and transforming growth factor-beta-1, helping suppress inflammation.
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Panax Ginseng Root Powder

Panax ginseng, well known for its medicinal properties, regulates each type of immune cell including, macrophages, natural killer cells, dendritic cells, T cells, and B cells. Ginseng can alleviate pathological symptoms and prevent potential diseases thanks to its anti-inflammatory, antioxidant, and homeostatic properties, as well as have other positive effects on your biological metabolism.
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GABA

GABA (Gamma-Aminobutyric Acid) is an inhibitory neurotransmitter in the nervous system that suppresses the sensation of pain and anxiety. It is the most prevalent inhibitory neurotransmitter with high concentrations in the brain and spinal cord and is present in 60-70% of all synapses in the central nervous system. GABA plays an important role in sensitivity for neuronal firing, mood, cognition, pain, sleep, and movement disorders.
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Boswellia Extract

Boswellia and its active ingredients, such as boswellic acid, have a good anti-inflammatory effect on the body. One of these acids, boswellic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation. Modern medicine and pharmacology strongly point out to its use as an antiarthritic, anti-inflammatory, anti-hyperlipidemic (controls blood lipids), anti-atherosclerotic (anticoronary plaque), analgesic (pain-reliever) and it being hepatoprotective (protects the liver).
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5-Hydroxytryptophan

5-Hydroxytryptophan, or 5-HTP for short, suppresses inflammation and arthritic pain by decreasing the production of pro-inflammatory mediators. It’s an amino acid, meaning it builds muscles, causes chemical reactions in the body, transports nutrients, prevents illness, and carries out other functions. We chose to formulate ProleevaMax using 5-HTP because it is the amino acid that metabolizes into serotonin, a neurotransmitter that controls mood and pain.
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L-Glutamine

Glutamine, an amino acid, is an abundant constituent of proteins. It was first isolated from gliadin, a protein present in wheat (1932). It is the only amino acid capable of readily crossing the barrier between blood and brain and, with glutamic acid, and is thought to account for about 80 percent of the amino nitrogen of brain tissue.
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L-Serine

Serine is needed for the production of tryptophan, an essential amino acid that’s used to make serotonin. It is also converted into D-serine in the cells of the nervous system. D-serine activates NMDA receptors in the brain that work as neurotransmitters. Research shows that it may work as a therapeutic agent for schizophrenia, depression, and cognitive dysfunction.
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Piperine

Piperine is added to enhance the bioavailability of curcumin and other ingredients for optimal therapeutic properties against chronic pain and inflammation. Studies also showed the anti-inflammatory effect of piperine isolated from black pepper through inhibiting enzymes (COX-2) and inflammatory cytokines (TNF-α and Interleukins-6) involved in the inflammatory cascade.
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Vitamin B6

Vitamin B6, also known as pyridoxine, belongs to the vitamin B family and is important for metabolism, immune response, neurotransmission, and other physiological functions. Studies on vitamin B6 revealed significant anti-inflammatory and analgesic potential in the management of various chronic medical conditions. It effectively inhibits the pro-inflammatory cytokines (TNF-α, interleukins) and also suppresses the enzymatic activity of inflammatory enzymes such as COX-2 and iNOs responsible for inflammatory cascade.
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ProleevaMax™ Is Here

Relief is on the way for those battling chronic conditions like Rheumatoid Arthritis, Fibromyalgia, and Osteoporosis.

ProleevaMaxis specially formulated to provide the comfort and support you need. Take the first step toward a pain-free life today.

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CITATIONS/REFERENCES FOR EACH INGREDIENT

Choline Bitartrate

  1. Kusuda R, Carreira EU, Ulloa L, Cunha FQ, Kanashiro A, Cunha TM. Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway. Brain Res. 2020 Jan 15;1727:146567. doi: 10.1016/j.brainres.2019.146567. Epub 2019 Nov 26. PMID: 31783002; PMCID: PMC7054728.
  2. Moretti A, Paoletta M, Liguori S, Bertone M, Toro G, Iolascon G. Choline: An Essential Nutrient for Skeletal Muscle. Nutrients. 2020 Jul 18;12(7):2144. doi: 10.3390/nu12072144. PMID: 32708497; PMCID: PMC7400816.
  3. Sidhu N, Davies S, Nadarajah A, Rivera J, Whittington R, Mercier RJ, Virag L, Wang S, Flood P. Oral choline supplementation for postoperative pain. Br J Anaesth. 2013 Aug;111(2):249-55. doi: 10.1093/bja/aet031. Epub 2013 Apr 7. PMID: 23568851; PMCID: PMC3841409.

5-HTP (5-hydroxytryptophan)

  1. Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020 Dec 26;22(1):181. doi: 10.3390/ijms22010181. PMID: 33375373; PMCID: PMC7796270.
  2. Caruso, I., Sarzi Puttini, P., Cazzola, M., & Azzolini, V. (1990). Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. The Journal of international medical research, 18(3), 201–209. https://doi.org/10.1177/030006059001800304
  3. Sarzi Puttini, P., & Caruso, I. (1992). Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. The Journal of international medical research, 20(2), 182–189. https://doi.org/10.1177/030006059202000210
  4. Titus, F., Dávalos, A., Alom, J., & Codina, A. (1986). 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. European neurology, 25(5), 327–329. https://doi.org/10.1159/000116030
  5. Shaw, K., Turner, J., & Del Mar, C. (2002). Tryptophan and 5-hydroxytryptophan for depression. The Cochrane database of systematic reviews, (1), CD003198. https://doi.org/10.1002/14651858.CD003198
  6. Kious, B. M., Sabic, H., Sung, Y. H., Kondo, D. G., & Renshaw, P. (2017). An Open-Label Pilot Study of Combined Augmentation With Creatine Monohydrate and 5-Hydroxytryptophan for Selective Serotonin Reuptake Inhibitor- or Serotonin-Norepinephrine Reuptake Inhibitor-Resistant Depression in Adult Women. Journal of clinical psychopharmacology, 37(5), 578–583. https://doi.org/10.1097/JCP.0000000000000754

L-arginine

  1. Morris CR, Kuypers FA, Lavrisha L, Ansari M, Sweeters N, Stewart M, Gildengorin G, Neumayr L, Vichinsky EP. A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes. Haematologica. 2013 Sep;98(9):1375-82. doi: 10.3324/haematol.2013.086637. Epub 2013 May 3. PMID: 23645695; PMCID: PMC3762093.
  2. Rondón, L. J., Farges, M. C., Davin, N., Sion, B., Privat, A. M., Vasson, M. P., Eschalier, A., & Courteix, C. (2018). L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration. European journal of nutrition, 57(7), 2353–2363. https://doi.org/10.1007/s00394-017-1508-x
  3. Hnia K, Gayraud J, Hugon G, Ramonatxo M, De La Porte S, Matecki S, Mornet D. L-arginine decreases inflammation and modulates the nuclear factor-kappaB/matrix metalloproteinase cascade in mdx muscle fibers. Am J Pathol. 2008 Jun;172(6):1509-19. doi: 10.2353/ajpath.2008.071009. Epub 2008 May 5. PMID: 18458097; PMCID: PMC2408412.
  4. Wu, T., Wang, C., Ding, L., Shen, Y., Cui, H., Wang, M., & Wang, H. (2016). Arginine Relieves the Inflammatory Response and Enhances the Casein Expression in Bovine Mammary Epithelial Cells Induced by Lipopolysaccharide. Mediators of inflammation, 2016, 9618795. https://doi.org/10.1155/2016/9618795

Gamma-Aminobutyric Acid (GABA) 99%

  1. Ngo DH, Vo TS. An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid. Molecules. 2019 Jul 24;24(15):2678. doi: 10.3390/molecules24152678. PMID: 31344785; PMCID: PMC6696076.
  2. Ngo DH, Vo TS. An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid. Molecules. 2019 Jul 24;24(15):2678. doi: 10.3390/molecules24152678. PMID: 31344785; PMCID: PMC6696076.

Glutamine

  1. Samuel Wilson, Frances Wright, Marcus A. Carden, L-Glutamine Decreases Opioid Use in Individuals with Sickle Cell Disease and Chronic Pain: A Case Series, Blood, Volume 134, Supplement 1, 2019, Page 4849, ISSN 0006-4971, https://doi.org/10.1182/blood-2019-126179.
  2. Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci. 2017 May 12;18(5):1051. doi: 10.3390/ijms18051051. PMID: 28498331; PMCID: PMC5454963.
  3. Coqueiro AY, Rogero MM, Tirapegui J. Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition. Nutrients. 2019 Apr 17;11(4):863. doi: 10.3390/nu11040863. PMID: 30999561; PMCID: PMC6520936.
  4. Córdova-Martínez A, Caballero-García A, Bello HJ, Pérez-Valdecantos D, Roche E. Effect of Glutamine Supplementation on Muscular Damage Biomarkers in Professional Basketball Players. Nutrients. 2021 Jun 17;13(6):2073. doi: 10.3390/nu13062073. PMID: 34204359; PMCID: PMC8234492.

L-Serine

  1. ZHOU, X., ZHANG, H., HE, L., WU, X. & YIN, Y. 2018. Long-Term l-Serine Administration Reduces Food Intake and Improves Oxidative Stress and Sirt1/NFκB Signaling in the Hypothalamus of Aging Mice. Frontiers in Endocrinology, 9.
  2. YE, L., SUN, Y., JIANG, Z. & WANG, G. 2021. L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury. Frontiers in Molecular Neuroscience, 14.
  3. Sasahara, I., Yamamoto, A., Takeshita, M., Suga, Y., Suzuki, K., Nishikata, N., Takada, M., Hashimoto, M., Mine, T., Kobuna, Y., & Nagao, K. (2020). l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. The Journal of nutrition, 150(9), 2278–2286. https://doi.org/10.1093/jn/nxaa156

Curcumin

  1. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. PMID: 23143785; PMCID: PMC3535097.
  2. Binion DG, Heidemann J, Li MS, Nelson VM, Otterson MF, Rafiee P Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcuminAm J Physiol Gastrointest Liver Physiol. (2009 Aug)
  3. Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activationBiochem Pharmacol. (1998 Mar 15)
  4. Di Pierro F, Rapacioli G, Di Maio EA, Appendino G, Franceschi F, Togni S Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophenJ Pain Res.(2013)
  5. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritisPanminerva Med.(2010 Jun)
  6. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patientsAltern Med Rev. (2010 Dec)

Boswellia Extract (Boswellia serrata)

  1. Perry TA1, Weerasuriya A, Mouton PR, Holloway HW, Greig NH. Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathyExp Neurol. (2004 Nov)

Piperine

  1. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. PMID: 23143785; PMCID: PMC3535097.
  2. Tripathi AK, Ray AK, Mishra SK. Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials. Beni Suef Univ J Basic Appl Sci. 2022;11(1):16. doi: 10.1186/s43088-022-00196-1. Epub 2022 Jan 28. PMID: 35127957; PMCID: PMC8796742.

Matcha Green Tea Extract

  1. Kochman J, Jakubczyk K, Antoniewicz J, Mruk H, Janda K. Health Benefits and Chemical Composition of Matcha Green Tea: A Review. Molecules. 2020 Dec 27;26(1):85. doi: 10.3390/molecules26010085. PMID: 33375458; PMCID: PMC7796401.
  2. Dietz, C., & Dekker, M. (2017). Effect of Green Tea Phytochemicals on Mood and Cognition. Current pharmaceutical design, 23(19), 2876–2905. https://doi.org/10.2174/1381612823666170105151800
  3. Sachdeva AK, Kuhad A, Tiwari V, Arora V, Chopra K Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome Basic Clin Pharmacol Toxicol. (2010 Jun)
  4. Unno K, Furushima D, Hamamoto S, Iguchi K, Yamada H, Morita A, Horie H, Nakamura Y. Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials. Nutrients. 2018 Oct 10;10(10):1468. doi: 10.3390/nu10101468. PMID: 30308973; PMCID: PMC6213777.

Panax Ginseng Root Powder

  1. Ratan ZA, Haidere MF, Hong YH, Park SH, Lee JO, Lee J, Cho JY. Pharmacological potential of ginseng and its major component ginsenosides. J Ginseng Res. 2021 Mar;45(2):199-210. doi: 10.1016/j.jgr.2020.02.004. Epub 2020 Mar 25. PMID: 33841000; PMCID: PMC8020288.
  2. Kim JH, Yi YS, Kim MY, Cho JY. Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J Ginseng Res. 2017 Oct;41(4):435-443. doi: 10.1016/j.jgr.2016.08.004. Epub 2016 Aug 18. PMID: 29021688; PMCID: PMC5628327.
  3. Braz, A. S., Morais, L. C., Paula, A. P., Diniz, M. F., & Almeida, R. N. (2013). Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 35(1), 21–28. https://doi.org/10.1016/j.rbp.2013.01.004
  4. Li MX, Wei QQ, Lu HJ. Progress on the Elucidation of the Antinociceptive Effect of Ginseng and Ginsenosides in Chronic Pain. Front Pharmacol. 2022 Feb 21;13:821940. doi: 10.3389/fphar.2022.821940. PMID: 35264958; PMCID: PMC8899510.

Resveratrol 98%

  1. Sahar Foshati;Mohammad Hossein Rouhani;Reza Amani; (2021). The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta‐analysis of controlled trials . International Journal of Clinical Practice, (), –. doi:10.1111/ijcp.14469
  2. Nallathambi R, Poulev A, Zuk JB, Raskin I. Proanthocyanidin-Rich Grape Seed Extract Reduces Inflammation and Oxidative Stress and Restores Tight Junction Barrier Function in Caco-2 Colon Cells. Nutrients. 2020 Jun 1;12(6):1623. doi: 10.3390/nu12061623. PMID: 32492806; PMCID: PMC7352846.
  3. Terra X, Valls J, Vitrac X, Mérrillon JM, Arola L, Ardèvol A, Bladé C, Fernandez-Larrea J, Pujadas G, Salvadó J, Blay M Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway J  Agric Food Chem. (2007 May 30)

Vitamin B6

  1. Bird R. P. (2018). The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis. Advances in food and nutrition research, 83, 151–194. https://doi.org/10.1016/bs.afnr.2017.11.004
  2. Du, X., Yang, Y., Zhan, X., Huang, Y., Fu, Y., Zhang, Z., Liu, H., Zhang, L., Li, Y., Wen, Q., Zhou, X., Zuo, D., Zhou, C., Li, L., Hu, S., & Ma, L. (2020). Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner. Journal of cellular and molecular medicine, 24(22), 13129–13138. https://doi.org/10.1111/jcmm.15917
  3. Ghavidel-Parsa, B., Naeimi, A., Gharibpoor, F. et al. Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial. BMC Musculoskelet Disord 23, 664 (2022). https://doi.org/10.1186/s12891-022-05637-7
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The views and nutritional advice expressed by Lanfam LLC are not intended for the purpose of providing medical advice. Please always consult your health care provider if you are taking any medications or have any medical conditions. Individual results may vary.
** The natural foods depicted in our product images are inspired by ingredients found in Proleevamax.